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Antigen presentation and T cell activation are shown through the close interaction between an antigen-presenting cell (APC) and a CD4⁺ T cell. An antigenic peptide is displayed on MHC class II molecules on the APC surface and recognized by the T cell receptor, with the CD4 coreceptor reinforcing this binding. Effective activation requires an additional co-stimulatory signal, represented by the interaction between B7 on the APC and CD28 on the T cell. Chemokine receptors on the T cell are also hi
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