The 49ers have six players on their report with injuries, and five have no game status designation while fully practicing Friday. Only starting cornerback Deommodore Lenoir is questionable. He was added to the report as limited Thursday with a calf injury suffered in practice and did not practice Friday.

Former Pro Bowl RB LeSean McCoy believes the Arizona Cardinals point shaved in their Week 11 loss to the San Francisco 49ers.

The San Francisco 49ers quarterback finally returned to action, and his wife Jenna had the perfect look for their baby daughter to celebrate.

San Francisco 49ers head coach Kyle Shanahan said he had big comebacks in mind when he kept Christian McCaffrey on the field with his team leading by 19 late in Sunday's game.

Five weeks after the San Francisco 49ers expected to have star wide receiver Brandon Aiyuk back from injury, the All-Pro wideout still has yet to be activated from the physically unable to perform list.

Ever since training camp last year, the San Francisco 49ers have been hit with one injury to a key player after another. They haven't gotten any type of respite from the injury bug, and it resulted in them going 6-11 and missing the playoffs last season after coming off a narrow loss in Super Bowl LVIII.

The 49ers head to State Farm Stadium to face the Arizona Cardinals with Brock Purdy back under center. Purdy was cleared off the injury report and is starting after missing six games with a turf-toe variant.

QB Brock Purdy connected with TE George Kittle for two touchdowns on the day, marking the 23rd touchdown pass that Purdy has thrown to Kittle. The duo's 23 touchdowns are the second-most by a 49ers QB/TE duo in franchise history.