Mahomes was down and in pain for several minutes and eventually had to be helped into the locker room by the training staff. Gardner Minshew entered in his place and played out the final drive for the Chiefs, only to be intercepted on his final pass attempt of the game, sealing both the loss and the Chiefs' fate.

The Tennessee Titans vs. Kansas City Chiefs matchup will look different in Week 16, after Patrick Mahomes was lost for the season with a torn ACL.

Browns star Myles Garrett sees shades of Patrick Mahomes and Lamar Jackson in Caleb Williams' elusive, dynamic playmaking ability.

Now, how he will fare is another story. Mahomes will be coming off by far the worst stretch of football of his career, and accuracy — especially down the field — that was a frustratingly persistent issue this season could be further marred by his lower body not yet being back to full strength.