The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

The San Francisco 49ers picked up a huge win in the NFC wild-card race on Monday night over the Carolina Panthers.

The Carolina Panthers made their first prime-time appearance in an NFL regular-season game since Nov. 9, 2023, on Monday night with an opportunity to take sole possession of the lead in the NFC South.

As the Panthers try to beat out the Buccaneers for the NFC South, Carolina has added some extra defensive depth.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The Panthers have been a resurgent force this year and may finally be ready to return to the playoffs for the first time since the 2017 season. The Panthers have won five of their last seven games and look to have finally found a franchise quarterback in Bryce Young.

With a win on "Monday Night Football," the Panthers would climb into first place in the NFC South. Here's a look at their playoff odds:

Pretenders fade when the lights get bright, and the Panthers faded tonight. It's totally fine to be a pretender at this stage with how bad the Panthers have been. Anyone realistically expecting playoffs heading in 2025 was fooling themselves,