The Cardinals placed Knight (ankle) on injured reserve Tuesday, Zach Gershman of the team's official site reports.

The Cardinals lost James Conner early on and then quickly lost his backup Trey Benson. That left Bam Knight, Michael Carter and Emari Demercado to share work. Knight has taken over as the lead back and due to goal line and passing down work, he’s managed to be useful as a flex play this season.

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Running back Bam Knight was carted to the X-ray room with a left ankle injury. The Cardinals list him as questionable to return, but Knight could not put any weight on his left leg and appeared in significant pain as he left. His only carry came on the Cardinals' first play from scrimmage when Derek Stingley tackled him for a 2-yard loss.

The Cardinals believe Knight (ankle), who is set for an MRI after having been carted off the field during Sunday's 40-20 loss to Houston, is dealing with a sprain, Adam Schefter of ESPN reports.

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The Cardinals have gained bad news as Trey Benson will not return from the IR, subsequently ending his 2025 season. This leads to an RB1 job up for debate.