Death is called the great equalizer. And while everyone must die, if you’re a Holy Roman Emperor eternal rest comes with some ...

The Thompson Brothers are back with another excellent Metroidvania. While there is the odd quibble to consider, Crypt ...

As people live longer, the gut quietly accumulates damage that can tip the balance between healthy tissue renewal and chronic ...

Scientists have uncovered a gut-specific epigenetic aging mechanism that links inflammation and iron imbalance to cancer risk ...

It probably sucked to be a Roman soldier guarding Hadrian’s Wall circa the third century CE. W.H. Auden imagined the likely harsh conditions in his poem “Roman Wall Blues,” in which a soldier laments ...

The quantitative measurement of intestinal crypts morphology and their architecture can provide valuable insights on the normal intestinal functioning and on subtle changes linked to disease onset and ...

EPFL scientists have shown that a gene linked to a rare childhood disease is essential for regenerating intestinal stem cells after injury. Our intestines are constantly renewing themselves, replacing ...

Polarized columnar epithelial cells form a delicate yet highly effective, single-cell-thick barrier that lines the intestine and other mucosal surfaces. Their function is to separate and actively ...

Mucosal glia in human and mouse small intestines widely express Plp1. C) Whole-mount immunostaining of ileum from an adult Plp1-eGFP mouse for GFAP imaged at the level of the villus-(top panels) and ...

This study presents important findings on the function of enteric glia expressing proteolipid protein 1 (PLP1+ glia). The evidence supporting the claims of the authors is solid, although the inclusion ...

The enteric nervous system (ENS) is often referred to as the “second brain” due to its complex neural networks that regulate gut function independently of the central nervous system. Within this ...