The Indianapolis Colts can't lose to the San Francisco 49ers, or their playoff hopes will fall into the abyss.

In the overall AFC playoff picture, the Colts remain on the outside looking in. They are the eighth seed and are one game behind the 9-5 Texans for the final wildcard spot. The other two wildcard teams, the LA Chargers and the Buffalo Bills, are both 10-4.

Seattle is a massive home favorite, given that the Colts will be starting a 44-year-old coming off the couch. Indianapolis wins in just 21% of the model's simulations, which offers notable value for the +700 Colts money line. Indy covers the big spread in 56% of the sims and the Over hits 59% of the time.

Andrew Luck, 36, retired shortly before the 2019 season and said the Colts didn't reach out to him about returning after Daniel Jones' injury

The Indianapolis Colts need to keep this weapon.

Expert recap and game analysis of the Seattle Seahawks vs. Indianapolis Colts NFL game from December 14, 2025 on ESPN.

The Seattle Seahawks narrowly edged out the Indianapolis Colts in a field goal battle, winning 18-16 to improve to 11-3 on the season. Relive the action with this recap blog.

Indianapolis Colts quarterback and former No. 4 overall pick Anthony Richardson received a positive injury update on Monday afternoon.