With four games left, Prescott is on pace to set career-highs in completion percentage (69%), completions and pass attempts (on pace for 436/632). Prescott has an impressive touchdown to interception ratio (26-10) and will likely finish above 4,500 passing yards as one of the league’s leading passers, if not the leader.

Backing Detroit is the way to go, according to the model. The Lions cover the 6-point spread in 58% of simulations, good for an "A" grade. Detroit wins in 46% of simulations to offer value as a plus-money underdog and the Under (55) hits in 59% of simulations.

In Sporting News' Week 12 picks and predictions, Los Angeles delivers a blow to Detroit's playoff hopes, while Buffalo splits an important AFC East series.

The Indianapolis Colts and Seattle Seahawks meet in a battle with playoff implications Sunday. Kickoff from Seattle, Washington, is 4:25 p.m. ET