NFL schedule is officially released, full of some very interesting matchups. While the opponents have been determined for months, we finally know when (and what network) the biggest matchups in the league will be taking place.

The Philadelphia Eagles, led by quarterback Jalen Hurts, meet the Dallas Cowboys, led by Dak Prescott, in a regular season game on Thursday, September 4, 2025, at Lincoln Financial Field in Philadelphia,

As of 5:30 p.m. EST on May 13, DraktKings Sportsbook sets the line at seven points with the Philadelphia Eagles as the favorites. The OVER/UNDER at that time was 46.5 points. The moneyline was -310 for the defending champs compared to +250 for the Dallas Cowboys. Keep in mind that game odds refresh periodically and are scheduled to change.

Even though the full NFL schedule won't be released until Wednesday, the Philadelphia Eagles' primetime lineup for 2025 is coming into focus. The NFL announced on Tuesday the defending Super Bowl champions will play the Green Bay Packers at Lambeau Field on Monday Night Football in Week 10.

The NFL just announced its 2025 season opener! The defending Super Bowl champions, the Philadelphia Eagles, will host the Dallas Cowboys in a big divisional clash. The Eagles open as early 7-point favourites.