The Louisville Cardinals could be without quarterback Miller Moss for the Week 13 ACC matchup against the SMU Mustangs.

Over on the defensive side of the ball, SMU has several impact playmakers. Safety Ahmaad Moses has an FBS-best five interceptions, safety Isaiah Nwokobia has a team-best 77 tackles and seven pass breakups, while linebacker Brandon Miyazono and corner Deuce Harmon also have seven PBUs.

An outlook that wasn't looking great before the ACC injury update hit Thursday night is a good bit darker a day before Louisville travels to SMU looking to end a

SMU will look to keep its hopes alive for an Atlantic Coast Conference championship on Saturday afternoon when the Mustangs welcome Louisville to Dallas.

The Mustangs return to Ford Stadium on Saturday to take on conference opponent Louisville on Senior Day. SMU is coming off of a bye week after earning a commanding 45-13 victory over Boston College the previous weekend, its largest margin of victory on the road since 2023.

Louisville running back Keyjuan Brown, who has filled in exceptionally for injured preseason All-American Isaac Brown, is now sidelined by injury himself, while quarterback Miller Moss

SMU returns to Ford Stadium on Saturday for senior day as the Mustangs try to keep their ACC title hopes alive with a win over Louisville. SMU head coach Rhett Lashlee gave praise to wide receiver Yamir Knight on his emergence as a Mustang.

Take a look at how the Cardinals stack up against the Mustangs for their Saturday matchup, and who the statistical models favor: