In Week 16, Brandon Aiyuk and the San Francisco 49ers will meet the Indianapolis Colts, on Monday at 8:15 p.m. ET. Game Time: 8:15 p.m.

Ricky Pearsall’s injury status and the ripple effects of major NFL injuries, including Micah Parsons and Patrick Mahomes. Brandon Aiyuk’s dramatic exit and MORE.

By placing Aiyuk on the reserve/left squad list, the 49ers sent the message that they don't need him anymore. And then, to ...

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

Brandon Aiyuk and the 49ers have apparently kept their relationship long-distance as a divorce inevitably looms.

Pass rush. Cam Ward came into the game having been sacked 49 times, tied for the most in the NFL. The Niners didn't bring him down once on 29 pass attempts as they remain last in the NFL with 16 sacks ...

The most recent move the San Francisco 49ers made involving Brandon Aiyuk suggested he may never suit up for this team again.

“Survivor 48” star Eva Erickson reveals she narrowly avoided Brown University shooting: 'So extremely lucky' Joe Burrow had ...

On Sunday, the 49ers beat Tennessee 37-24, and Aiyuk's replacement, Ricky Pearsall, had six catches for 96 yards. So before ...

"Yeah, I think I don't get wrapped up in 'oh this guy hasn't gotten the ball, so I need to force it to him.' I got to go ...

The San Francisco 49ers are set to part ways with WR Brandon Aiyuk, and head coach Kyle Shanahan didn't mince words when ...

San Francisco 49ers head coach Kyle Shanahan has made a shocking admission about the fallout with Brandon Aiyuk.