The highest snow accumulations are expected east of Lake Ontario, where some isolated areas could be hit by up to 60 inches of lake-effect snow by early next week.

An arctic blast of severe cold and snow is creating hazardous conditions across the Great Lakes region over the next two days, according to the US Weather Prediction Center, potentially disrupting the plans of millions traveling the roads and skies.

CBS New York meteorologist John Elliott said "very intense snow" will hit communities along the Great Lakes, Plans and Midwest regions as upwards of 6 feet of snow is forecast.

An Arctic blast brought snow, frost and dangerously cold winds to the northern Plains, Midwest and Great Lakes, creating difficult travel conditions on one of the busiest travel days of the year, as millions of Americans head home from their Thanksgiving destinations.

A blast of Arctic air taking over much of the U.S. this weekend is bringing powerful lake-effect snow to several states, including Pennsylvania and New York, and shivering temperatures to parts of the South.