The Tennessee Titans, led by quarterback Cam Ward, face the San Francisco 49ers, led by quarterback Brock Purdy, on Sunday, ...

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the ...

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to ...

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

The NFC West is clearly the most dominant division in the football this season with three teams with 10+ wins with three ...

Cleveland Browns All-Pro edge rusher Myles Garrett is on the doorstep of NFL history. His 21.5 sacks lead the league by a ...

Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five ...

Paul Wiggin's four-year run as Stanford's head coach was not his first or last act in football, but his career transcended ...

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.

The 49ers and Panthers are in the thick of the NFC playoff race. USA TODAY Sports provided updates, highlights and more from ...