Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

Since scientists first discovered that human immune cells could be modified to become cancer-fighting agents, they've been trying to engineer a cell that's effective against solid tumors, which ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Study supports utility of host-response testing in febrile neutropenia patients with haematological malignancies which may be the only indication of severe underlying infections ...

New findings from Karolinska Institutet reveal how the gene HNRNPU coordinates several fundamental molecular processes during ...

New findings from Karolinska Institutet reveal how the gene HNRNPU coordinates several fundamental molecular processes during ...

A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic ...

A large genetic screen has revealed how stem cells transform into brain cells, exposing hundreds of genes that make this process possible. Among the discoveries is PEDS1, a gene now linked to a ...

Syntax Bio, a synthetic biology company programming the next generation of cell therapies, today announced the publication of new research in Science Advances detailing the company's CRISPR-based ...

Transient gene expression (TGE) is commonly used for the rapid production of protein-based therapeutics, including antibodies that require post-translational modifications. We previously published a ...