Brock Purdy remained limited in a Thanksgiving Day practice, keeping his status in doubt for the 49ers’ game Sunday at Buffalo. Purdy missed last Sunday’s 38-10 loss at Green Bay because of a shoulder injury that’s impaired his throwing ability since the previous game’s loss to Seattle.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.

San Francisco 49ers left tackle Trent Williams may be at risk of missing his second consecutive game. On Sunday, the offensive lineman was sidelined against the Green Bay Packers due to an ankle injury and did not participate in Wednesday's practice.