Albert Breer and Kyle Brandt argue that San Francisco 49ers coach Kyle Shanahan deserves consideration for the 2025 NFL Coach of the Year award.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

Brock Purdy still believes the San Francisco 49ers can return to the NFL playoffs and make a run at a Super Bowl ring despite their injuries.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) Sunday in Week 11. Kickoff from State Farm Stadium in Glendale, Arizona, is at 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.

49ers' Mac Jones expected to draw trade interest, according to NFL insider originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have been one of the more banged-up teams in the NFL. Brock Purdy, the $262 million starting quarterback, has missed most of the season.