Ammonia can be produced by the break-down of amino acids, or by the gut bacteria in humans. If the level of ammonia in the blood becomes too high, then it becomes toxic to the brain. The urea cycle ...

Urea cycle disorders are congenital diseases that are caused by a dysfunctional urea cycle. The genetics and biochemistry of these disorders have been extensively studied. They are the result of a ...

Arginase deficiency is a rare autosomal recessive metabolic disorder that disrupts the final step of the urea cycle, impairing the conversion of arginine into urea and ornithine. In affected ...

Urea cycle disorders (UCDs) constitute a group of rare, inherited metabolic conditions arising from deficiencies in key enzymes of the urea cycle – the biochemical pathway responsible for converting ...

A urea cycle disorder is a genetic condition which elevates the blood ammonia concentration above the normal level. A urea cycle disorder (UCD) is a genetic condition brought about by gene mutations ...