Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how to watch live and streaming.

The Colts host the 49ers on tonight’s edition of Monday Night Football. The 49ers/Colts game begins at 8:15 p.m. ET on ESPN. Nope. But the Manning boys will return to ESPN2 for the Monday night wild-card matchup on January 12.

Caesars Sportsbook pioneered live streaming NFL games in December 2022 by launching its "Watch & Bet" feature for both regular-season and playoff matchups. Since then, Caesars has improved the experience with "BetVision," a built-in viewing tool that lets you watch games, check live odds, place bets, and manage your bet slip all in one place.

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The San Francisco 49ers and Indianapolis Colts take the field for NFL Monday Night Football tonight in Week 16. MNF start time, TV schedule and how to watch.