Notch, a protein known to govern the determination of cell differentiation into different kinds of tissues in embryos, plays a critical role in bone formation and strength later in life, said ...

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival ...

The Notch pathway regulates cell fate decisions during embryonic development by facilitating short-range signalling between neighbouring cells that are in physical contact. Initially discovered for ...

A Protein Notch, which helps in determining cell differentiation into different kinds of tissues in embryos also helps in bone formation and bone strength in later years. A protein called Notch was ...

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice. The study, led by researchers from NYU Grossman School of Medicine, ...

We address the mechanisms underlying generation of skeletal muscle, smooth muscle, and endothelium from epithelial progenitors in the dermomyotome. Lineage analysis shows that of all epithelial ...