Friend erythroleukemia cells of line Fw are noninducible for hemoglobin synthesis by dimethyl sulfoxide, butyric acid, and other agents. However, these agents were found to induce hemoglobin synthesis ...

Defects in the gene encoding β-globin, a component of adult haemoglobin, cause β-globinopathies such as sickle cell disease and β-thalassaemia. Disease symptoms can be alleviated by the induction of ...

This is a preview. Log in through your library . Abstract When murine erythroleukemia (MEL) cells are induced with hemin, they carry out several early functions of the erythroid program. However, they ...

Our ability to breathe oxygen is critical to our survival. This process is mediated by the hemoglobin in our blood, which carries oxygen. Since air contains less oxygen on high mountains, the body is ...

THE typical case of spontaneously occurring pyridoxine-responsive anemia in human beings has been characterized by hypochromic, microcytic red cells, normoblastic proliferation in the bone marrow, ...

The blood protein hemoglobin and its relative, myoglobin, carry and store life-giving oxygen in many animals. Researchers long thought these complex proteins, with their unique fold, were the only two ...

FIGURE 1. Distribution of different genotypes with α-globin gene triplication in 73,967 subjects. (A) Gender distribution. (B) The proportion of different genotypes among 1,443 α-globin gene ...