Schematics showing the arrangement of cells in normal epithelial tissue (a), following the introduction of a topological defect (b) and the site of cell death and extrusion following the appearance of ...

Figure 3: Compressive stresses at +1/2 defects trigger both cell extrusion and YAP mechanosensitive response and can be modulated by cell–cell junction strength. We conclude that an epithelial cell ...

Knee osteoarthritis (OA) is a disease characterized primarily by the wear of articular cartilage due to aging 1. Elucidating the process underlying its morphological progression is crucial for ...

Researchers have discovered the primary mechanism driving the extrusion of dying cells from epithelial monolayers. Researchers from the Mechanobiology Institute, Singapore (MBI) at the National ...