If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Single-cell analysis helps uncover how the BK virus replicates, opening the door to new drug targets. BK polyomavirus (BKPyV) is a major cause of kidney transplant failure. Without a complete ...

Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist ...

Cancer cells frequently rely on backup mechanisms and alternative, often mutagenic, pathways to repair DNA damage. These adaptations enable cancer cells to survive and proliferate in hostile ...

Creating artificial systems that mimic the functioning of cells is one of the goals of what is known as synthetic biology. These models, known as synthetic or biomimetic cells, allow some of the basic ...

Directed evolution in mammalian cells offers a powerful approach for advancing synthetic biology applications. However, existing mammalian-based directed evolution methods face substantial bottlenecks ...

Researchers at The University of Texas MD Anderson Cancer Center have identified a key enzyme—RNase H2—that helps triple-negative breast cancer (TNBC) cells survive high levels of DNA replication ...