Nature

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...
Nature

MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells

DCs loaded with tumor antigens have been shown to inhibit tumor growth in several mouse models. 6,7 Methods used to load tumor antigen in these studies include pulsing DCs with defined peptide ...
Nasdaq

Gritstone Oncology Announces Oral Presentation on MHC Class II Antigen Prediction at the AACR Annual Meeting in April 2019

EMERYVILLE, Calif., Feb. 27, 2019 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq:GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight ...
JSTOR Daily

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

Many cancers evade immune rejection by suppressing major histocompatibility class I (MHC-I) antigen processing and presentation (AgPP). Such cancers do not respond to immune checkpoint inhibitor ...
JSTOR Daily

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Trims MHC Class I-Presented Peptides in vivo and Plays an Important Role in Immunodominance

CD8⁺ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate ...