Ruggiano and Ramadan 4 provide an overview of the mechanisms dedicated to removing replication obstacles, such as proteins covalently or tightly bound to DNA. Their work discusses how molecular ...

Fig. 4: The process of establishment of pre-RCs at an S. cerevisiae origin in which the B2 domain is separated from the A and B1 origin elements. This Review focuses on the first step in eukaryotic ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...