After winning their first two games of the season, the San Francisco 49ers return home in Week 3 to host the Arizona Cardinals at Levi's Stadium.

The San Francisco 49ers are 2-0 and right on schedule, despite suffering numerous injuries on the offensive side of the ball. Kyle Shanahan’s scheme and play-calling remain king, while Robert Saleh’s defense has gotten enough stops through two games for the Niners to win two road games, which is no easy feat, regardless of opponent.

The Arizona Cardinals and San Francisco 49ers won't see each other until Week 3 - though a massive name will now officially be absent in the NFC West

At the center of the most worrisome developments is quarterback Brock Purdy, who sustained a turf-toe variant plus a left shoulder issue in Week 1 and has been ruled out for Sunday's game in New Orleans.

The 49ers secure a 26-21 win against the Saints, moving to 2-0 despite quarterback injuries. Discover the game highlights.

The 49ers will look to start 3-0 for the third time in the Kyle Shanahan era when they play the Cardinals in their home opener. The previous two times came in 2019 and 2023, when San Francisco finished 13-3 and 12-5, respectively. Both those seasons ended in Super Bowl losses to the Chiefs.

The New Orleans Saints took another loss in Week 2, this time to the 49ers, but there were some positives which could build up and turn the tide: