There are always a few things to learn from the San Francisco 49ers in every win or defeat. That includes an expected 41-22 win against the Arizona Cardinals. W

San Francisco 49ers tight end George Kittle (85) catches a touchdown pass in front of Arizona Cardinals linebacker Akeem Davis-Gaither (27) during the first half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin

San Francisco 49ers WR Skyy Moore reflected on his 98-yard opening kickoff return and shared his reaction to the Faithful taking over State Farm Stadium in the 49ers Week 11 win over the Arizona Cardinals,

ARIZONA -- The Arizona Cardinals are no strangers to adjusting to opposing fans at State Farm Stadium, though the San Francisco 49ers tend to travel among the best in the NFL in terms of away support.

The San Francisco 49ers had more players suffer injuries in Week 11 against the Arizona Cardinals. Here's what Kyle Shanahan said about

Sunday will be the 2025 debut for Arizona Cardinals outside linebacker BJ Ojulari. Among the roster moves the Cardinals made on Saturday ahead of their Sunday game in Week 11 against the San Francisco 49ers, Ojulari was activated from the PUP (physically unable to perform) reserve.

The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The San Francisco 49ers improved to 7-4 on the season after a 41-22 Week 11 win over the Arizona Cardinals at State Farm Stadium in Glendale, Arizona. Below are several statistics and notes from Sunday's game,