The highest snow accumulations are expected east of Lake Ontario, where some isolated areas could be hit by up to 60 inches of lake-effect snow by early next week.

CBS New York meteorologist John Elliott said "very intense snow" will hit communities along the Great Lakes, Plans and Midwest regions as upwards of 6 feet of snow is forecast.

A blast of Arctic air taking over much of the U.S. this weekend is bringing powerful lake-effect snow to several states, including Pennsylvania and New York, and shivering temperatures to parts of the South.