San Francisco 49ers kicker Eddy Piñeiro and linebacker Tatum Bethune have been standouts as in-season substitutes, but both will miss several games after injuries sustained against the Cardinals.

San Francisco 49ers head coach Kyle Shanahan provided an unfortunate injury return timeline update for Brandon Aiyuk.

There are always a few things to learn from the San Francisco 49ers in every win or defeat. That includes an expected 41-22 win against the Arizona Cardinals. W

Brock Purdy still believes the San Francisco 49ers can return to the NFL playoffs and make a run at a Super Bowl ring despite their injuries.

Kyle Shanahan said Brock Purdy "checked out all right" after his first game back. Linebacker Tatum Bethune, however, didn't fare as well.

Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

While the 49ers waived Martinez to make room for defensive end Clelin Ferrell, they're not planning on Martinez being gone long according to head coach Kyle Shanahan. Shanahan on Monday in a conference call said Martinez was an option to return to the practice squad. NFL Media's Ian Rapoport later reported Martinez would be rejoining the 49ers.

ARIZONA -- The Arizona Cardinals are no strangers to adjusting to opposing fans at State Farm Stadium, though the San Francisco 49ers tend to travel among the best in the NFL in terms of away support.

Brock Purdy came through the Arizona game healthy, but kicker Eddy Piñeiro and linebacker Tatum Bethune did not.

The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs to be.

The 49ers drafted Martin to play their WILL spot, which is the weakside linebacker spot. This is the position Dee Winters plays, not Warner and Bethune. Warner played the MIKE, which is in the middle, and gets the defense aligned. The WILL is more about run-and-chase. They are asked to do different things.